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Accession number;99A0228192
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| Title;Dual recognition of the cyclodextrin conjugated with natural oligosaccharide. |
| Author;
HATTORI KENJIRO
(Tokyo Inst. of Polytech.)
YASUDA NAOYOSHI
(Tokyo Inst. of Polytech.)
YAMAZAKI TOMOHIRO
(Tokyo Inst. of Polytech.)
TSURUI HISAYO
(Tokyo Inst. of Polytech.)
INAZU TOSHIYUKI
(Noguchi Inst.)
MIZUNO MAMORU
(Noguchi Inst.)
YAMANOI TAKASHI
(Noguchi Inst.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.13th;NO.;PAGE.10-12(1998)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The synthesis of an oligosaccharide-branched cyclodextrin(CD) was investigated. And it showed potential binding to the saccharide-interacting protein, lectin, as well as cholic acid. Fmoc-Asn(GlcNAc2-Man6)-OH was synthesized in 88% yield by the reaction of Fmoc-OSu and Asn(GlcNAc2-Man6)-OH which was prepared by the digestion of ovalbumin. The reaction of Fmoc-Asn(GlcNAc2-Man6)-OH and 6-mono-amino-.BETA.-CD with PyBop in NMP gave the desired natural oligosaccharide-branched CD in 74% yields. The dual moleculer recognition concerning oligosaccharide recognition of Fmoc-Asn(GlcNAc2-Man6)-NH-CD with conconavalin A and also inclusion association with a guest molecule in CD's cavity using optical biosensor. This study showed that the oligosaccharide-branched CD formed a ternary complex and that there was the possibility of Asn(GlcNAc2-Man6)-NH-CD as a drug carrier for targeting drug delivery system. (author abst.) |
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