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Accession number;99A0228196
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| Title;Characteristics of Ionic Currents by Transmembrane Ion Channel from Cholic Acid Derivative. |
| Author;
KOBUKE YOSHIAKI
(Advanced Inst. Sci. and Technol., Nara)
NAGATANI TAKESHI
(Shizuoka Univ., Fac. of Eng.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.13th;NO.;PAGE.22-24(1998)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Two cholic acid 7,12-dimethyl ether derivatives were connected via bisurethane linkage at the 3-hydroxyl position to afford membrane-penetrating ion channel. It gave single ion channel currents of conductivity range 5-20pS with stable open states. The channel was cation selective, K+/Cl- selectivity being as large as 10. Furthermore, this channel discriminated K+ from Na+ by a factor of 3.5. (author abst.) |
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