Inclusion Abilities of Amide Derivatives of Bile Acids for Aliphatic Alcohols-Crystallographic Analyses.
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Accession number;99A0228197
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| Title;Inclusion Abilities of Amide Derivatives of Bile Acids for Aliphatic Alcohols-Crystallographic Analyses. |
| Author;
HISHIKAWA YUKIO
(Osaka Univ., Grad. Sch.)
AOKI YURIKO
(Osaka Univ., Grad. Sch.)
SADA KAZUKI
(Osaka Univ., Grad. Sch.)
MIYATA MIKIJI
(Osaka Univ., Grad. Sch.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.13th;NO.;PAGE.25-27(1998)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have been extensively studied inclusion phenomena and crystal structures of bile acids and their derivatives. In this report, we forcus on inclusion phenomena and crystal structures of amide derivarives (CAM, DCAM, CDCAM, LCAM) of the bile acids with a series of aliphatic alcohols. Both CAM and DCAM include all of them. In contrast, recrystallizafions of CDCAM from the alcoholic solvents give inclusion crystals of CDCAM with water. LCAM includes mainly isomers of C5H12O and C6H14O. These inclusion abilities are supported by X-ray crystallographic studies. CAM, DCAM and LCAM arrange in bilayered fashions and accommodate various guests into the channels which laying in lipophilic layers. On the other hand, CDCAM does not form a channel-type bilayered structure. Furthermore, CAM and DCAM can form a variety of polymorphs of host assemblies dependent on guest alcohols, while LCAM can a few. Accordingly, it can be seen that the inclusion abilities toward aliphatic alcohols depend on both the channel-type bilayered structures and the variety of the guest-dependence polymorphs. (author abst.) |
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