Science Links Japan | Presence of the first and second rules relating with the immuno-affinity and -specificity of antibodies.

Presence of the first and second rules relating with the immuno-affinity and -specificity of antibodies.

Accession number;99A0228220

Title;Presence of the first and second rules relating with the immuno-affinity and -specificity of antibodies.

Author; HIFUMI EMI (Hiroshima Prefectural Univ.) ISHIMARU MASANORI (Hiroshima Prefectural Univ.) MIZOGUCHI YOSHINORI (Hiroshima Prefectural Univ.) UDA TAIZO (Hiroshima Prefectural Univ.)

Journal Title;Abstracts. Symposium on Biofunctional Chemistry

Journal Code:L0836A

ISSN:

VOL.13th;NO.;PAGE.94-96(1998)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;The maturation mechanism of affinity is very important from view points of the science of the immunochemistry and the technologies making use of antibodies. There are unsolved items with respect to: a) how strongly the affinity matures in the antibody and b) to what extent the cross-reactivity can be suppressed. For these questions, we have found suggestive two physico-chemical rules. Immunoaffinity maturation obeys a power function rule (the first rule) and that the cross-reactivity potential of the antibody is limited by a immunochemical version of Hammett's rule (the second rule). From the first rule, even genetic rearrangements and point mutations should obey the physico-chemical rules, these have been hitherto considered to be occurred randomly. From the second rule, even if the antibodies are highly diversity, it is not recruited that the antibody has the different immunoaffinity by ten thousands fold or more for the structurally very similar molecules. (author abst.)

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