Fluorescence Responses of a .GAMMA.-Cyclodextrin-Diazacrown-Pyrene Conjugated Host for Deoxycholic Acids.
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Accession number;99A0228236
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| Title;Fluorescence Responses of a .GAMMA.-Cyclodextrin-Diazacrown-Pyrene Conjugated Host for Deoxycholic Acids. |
| Author;
SUZUKI IWAO
(Tohoku Univ., Fac. of Pharm.)
ITO MAKI
(Tohoku Univ., Fac. of Pharm.)
OSA TETSUO
(Tohoku Univ., Fac. of Pharm.)
ANZAI JUN'ICHI
(Tohoku Univ., Fac. of Pharm.)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.13th;NO.;PAGE.142-144(1998)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A new host compound (1), which was comprised of .GAMMA.-cyclodexrin, azacrown, and pyrene moieties, could form stable inclusion complexes with deoxycholic acids, with the stability constants being 10000-20000M-1. The complexation process could be monitored by fluorescence spectral changes; namely the complexation induced a large decrease in excimer fluorescence originating from an association dimer of 1 and an increase in normal fluorescence whose intensity was controlled by photo-induced electron transfer(PET) between the excited pyrene ring and the amino group of the azacrown moiety. Among four common deoxycholic acids, chenodeoxycholic acid, ursodeoxycholic acid, and hyodeoxycholic acid induced similar fluorescence spectral changes to one another. Deoxycholic acid itself, which has a hydroxyl group near the steroidal side chain, also largely decreased the excimer fluorescence but the extent an increase in the normal fluorescence was limited. These results indicated that 1 could recognize the position of the hydroxyl group through hydrogen bonding upon binding deoxycholic acid, and that the conformation of the complex between 1 and deoxycholic acid was different from those between 1 and the other deoxycholic acids. (author abst.) |
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