Recognition of Steroids and Peptides by Imprinted Cyclodextrin Polymer.
|
Accession number;99A0228237
|
| Title;Recognition of Steroids and Peptides by Imprinted Cyclodextrin Polymer. |
| Author;
HISHIYA TAKAYUKI
(Univ. of Tokyo, Grad. Sch.)
SHIBATA MASAHIKO
(Univ. of Tokyo, Grad. Sch.)
ASANUMA HIROYUKI
(Univ. of Tokyo, Grad. Sch.)
KOMIYAMA MAKOTO
(Univ. of Tokyo, Grad. Sch.)
|
Journal Title;Abstracts. Symposium on Biofunctional Chemistry
|
Journal Code:L0836A
|
ISSN:
|
|
VOL.13th;NO.;PAGE.145-147(1998)
|
| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have successfully applied this technique to regulate the conformation of cyclodextrins(CyDs) in the cross-linked polymer complementary to the large molecules. In the present study, molecularly imprinted CyD polymers are synthesized by using steroids and peptides, as templates. The .BETA.-CyD polymer prepared in the presence of cholesterol as a template exhibited higher adsorption activity toward cholesterol than the polymer prepared in the absence of the template. The imprinted polymer (cholesterol as template) also showed higher affinity for stigmasterol, whereas it did not for progesteron, whose size is smaller than cholesterol. Thus, the present imprinted polymer has a reasonable selectivity for steroids. The present molecularly imprinting technique is also applicable to the synthesis of peptide receptor. The imprinting effect was clearly observed when a peptide was used as template. In conclusion, molecularly imprinted polymers of CyDs are quite useful for the recognition of large molecules such as steroids and peptides. (author abst.) |
|
|
|
Related Articles;
|
|
