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Accession number;99A0203867
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| Title;Effect of Combination Chemotherapy with Mitomycin C and Cisplatin on Advanced Gastric Carcinoma. |
| Author;
HOSHIYA YASUNORI
(Shimizu-shiritsu Byoin)
WATAHIKI YOICHI
(Shimizu-shiritsu Byoin)
KOSAKA AKIO
(Shimizu-shiritsu Byoin)
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Journal Title;Japanese Journal of Cancer and Chemotherapy
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Journal Code:Z0938A
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ISSN:0385-0684
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VOL.26;NO.1;PAGE.145-148(1999)
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| Figure&Table&Reference;FIG.3, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 71-year-old male with advanced gastric carcinoma with paraaortic lymph node metastases underwent distal gastrectomy. Cisplatin (CDDP) 50mg/body was administered intravenously(iv) on day 1 followed by the administration of 5-fluorouracil 500mg/body/day iv on day 2 through day 7. After two courses of this regimen, further enlargement of paraaortic lymph nodes was revealed by CT scan, and chemotherapy was suspended. Multiple liver and lung metastases were diagnosed 6 months after initial diagnosis, and mitomycin C(MMC) 10mg/body iv was administered on day 1 followed by CDDP 50mg/body iv on day 2. After three courses of this regimen, partial response of the liver metastases and complete response of the lung metastases were observed, and the general condition was markedly improved without any adverse effect except slight nausea. Though the patient died of brain metastases one year after initial diagnosis, the combination chemotherapy with MMC and CDDP was nevertheless thought to improve his quality of life. (author abst.) |
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