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Accession number;99A0203869
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| Title;A Case of Unresectable Pancreatic Cancer Responding to MTX/5-FU Sequential Therapy. |
| Author;
TAKAHASHI NAONORI
(Sendai Natl. Hosp.)
MASAMUNE RYOCHI
(Sendai Natl. Hosp.)
KUNII YASUO
(Sendai Natl. Hosp.)
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Journal Title;Japanese Journal of Cancer and Chemotherapy
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Journal Code:Z0938A
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ISSN:0385-0684
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VOL.26;NO.1;PAGE.153-155(1999)
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| Figure&Table&Reference;FIG.2, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 66-year-old woman was admitted to our hospital complaining of abdominal pain and jaundice. Upper gastrointestinal series and computed tomography revealed pancreatic cancer. Pancreatectomy could not be performed bacause of portal invasion and multiple liver metastasis. Cholecystectomy, choledochojejunostomy and gastrojejunostomy were performed. The patient was treated with methotrexate(MTX) 100mg/m2 iv followed one hour later with 5-fluorouracil(5-FU) 700mg/m2. Leucovorin rescue of 10mg po was given 24 hours after MTX administration. Treatment was repeated every 14 days. As a result, the size of a primary tumor of the pancreas was reduced (42%) on computed to-mography, and the CEA level decreased to 27.8ng/ml from 84 ng/ml. No side effects were observed. The patient continued to receive chemotherapy at our outpatient clinic for 20 months. She died of exacerbation of carcinomatous peritonitis 23 months after initial admission. Therefore, we conclude that MTX/5-FU sequential therapy seems beneficial to manage advanced pancreatic carcinoma from the viewpoint of antineoplasic activity as well as quality of life. (author abst.) |
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