Facile Synthesis of a Phosphotriester Intermediates for Solution-Phase Preparation of Oligonucleotide Phosphorothioates.

Accession number;99A0156436
Title;Facile Synthesis of a Phosphotriester Intermediates for Solution-Phase Preparation of Oligonucleotide Phosphorothioates.
Author; MIYASHITA T (Yamasa Corp., Chiba) MORI K (Yamasa Corp., Chiba) SHINOZUKA K (Gunma Univ., Gunma)
Journal Title;Chem Lett
Journal Code:S0742A
ISSN:0366-7022
VOL.;NO.1;PAGE.39-40(1999)
Figure&Table&Reference;TBL.1, REF.14
Pub. Country;Japan
Language;English
Abstract;Fully protected 2'-deoxynucleoside phosphorothioate triester derivatives, which are key starting materials for the large-scale solution-phase preparation of phosphorothioate oligonucleotides, were easily synthesized by a new method starting from common, fully protected 2'-deoxynucleosides. (author abst.)
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