Inhibition of Corneal Neovascularization. The Possibility of Inhibition by Drug Administration.
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Accession number;99A0207594
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| Title;Inhibition of Corneal Neovascularization. The Possibility of Inhibition by Drug Administration. |
| Author;
NII SEIJI
(Sch. of Med., Keio Univ.)
IDEI TAKESHI
(Sch. of Med., Keio Univ.)
TERANO HIROSHI
(Fujisawa Pharm. Co., Ltd.)
MASHIMA YUKIHIKO
(Sch. of Med., Keio Univ.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.103;NO.1;PAGE.12-17(1999)
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| Figure&Table&Reference;FIG.8, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: The anti-angiogenic activity of FR 118487, a new synthetic analog of Scolecobasidium arenarium products, was examined in Japanese white rabbit cornea. Methods: We studied both systemic and locally administerad FR 118487(ointment) in a keratoplasty model consisting of corneal neovascularization after implantation of a Wister rat cornea into a rabbit cornea. Results: Two weeks after the implantation, the maximum length of neovascularization was 3.4.+-.0.3mm in control corneas, 0.1.+-.0.0mm with systemic FR 118487 administration(10mg/day)(p<0.01), 0.1.+-.0.1mm with 10% FR118487 ointment(p<0.001), 1.0.+-.0.2mm with 3% FR 118487 ointment(p<0.001), and 0.9.+-.0.9mm with 1% FR 118487 ointment(p<0.02). Conclusion: FR 118487 had a significant effect on inhibition of corneal neovascularization. (author abst.) |
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