Antagonistic Interaction between Clostridium butyricum and Enterohemorrhagic Escherichia coli O157:H7.
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Accession number;99A0269802
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| Title;Antagonistic Interaction between Clostridium butyricum and Enterohemorrhagic Escherichia coli O157:H7. |
| Author;
TAKAHASHI MOTOMICHI
(Miyarisan Pharm. Co., Ltd.)
TAGUCHI HARUHIKO
(Kyorin Univ., Fac. of Med.)
YAMAGUCHI HIROYUKI
(Kyorin Univ., Fac. of Med.)
OSAKI TAKAKO
(Kyorin Univ., Fac. of Med.)
SAKAZAKI RIICHI
(Nippon Inst. for Biol. Sci.)
KAMIYA SHIGERU
(Kyorin Univ., Fac. of Med.)
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Journal Title;Journal of the Japanese Association for Infectious Diseases
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Journal Code:Z0760A
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ISSN:0387-5911
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VOL.73;NO.1;PAGE.7-14(1999)
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| Figure&Table&Reference;FIG.4, TBL.3, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Antagonistic interaction between Clostridium butyricum strain MIYAIRI 588 and enterohemorrhagic Escherichia coli(EHEC) strain O157:H7 006 was examined using streptomycin-treated SPF mice and germ free mice. All SPF mice pretreated with streptomycin were colonized with EHEC O157:H7. On the other hand, only 20% of the SPF mice pretreated with streptomycin and C. butyricum were colonized with EHEC O157:H7. In addition, germ free mice died within 4-7 days after infection with EHEC O157:H7. In contrast, all gnotobiotic mice mono-associated with C. butyricum survived after the challenge with EHEC O157:H7. Both the number of EHEC and the amounts of shiga-like cytotoxin (SLT, type 1 and type 2) in fecal contents of gnotobiotic mice treated with C. butyricum were less than those of mice infected with only EHEC O157:H7. In conclusion, the probiotic bacterium, C. butyricum strain MIYAIRI 588, has a preventive effect against EHEC O157:H7 infection. (author abst.) |
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