Serotypes of Human Rotaviruses in 7 Regions of Japan from 1984 to 1997.

Accession number;99A0269806
Title;Serotypes of Human Rotaviruses in 7 Regions of Japan from 1984 to 1997.
Author; ZHOU Y (Univ. Tokyo) HASEGAWA A (National Inst. Infectious Diseases) CHIBA S (Sapporo Medical Univ.) NISHIMURA T (Hokusetsu General Hospital) YAMANISHI S (Kagawa Prefectural Inst. Health) FUNATSUMARU S (Saga Prefectural Inst. Health) MOTOHIRO T (Yukari Gakuen) UEDA Y (Maizuru Kyosai Hospital) NISHIO O (National Inst. Public Health)
Journal Title;Journal of the Japanese Association for Infectious Diseases
Journal Code:Z0760A
ISSN:0387-5911
VOL.73;NO.1;PAGE.35-42(1999)
Figure&Table&Reference;TBL.3, REF.19
Pub. Country;Japan
Language;English
Abstract;Human rotavirus(HRV) serotypes were studied from diarrheal stool specimens in children in 7 regions of Japan (Sapporo, Tokyo, Maizuru, Osaka, Kagawa, Kurume, and Saga) from 1984 to 1997 by enzyme immunoassay(EIA) with serotype-specific monoclonal antibodies against serotypes 1, 2, 3 and 4. In addition, reverse transcription-polymerase chain reaction(RT-PCR) was conducted for analysis of "others" which included nonserotypable and mixed-serotype rotavirus specimens by EIA. In 3756 rotavirus-positive specimens, serotype 1 was detected in 2649 (70.5%), serotype 2 in 362 (9.6%), serotype 3 in 232 (6.2%) and serotype 4 in 196 (5.2%). Overall, serotype 1 was predominant from 1984 to 1997, although there were a few cases in which serotype 2, 3 and 4 became predominant based on area and year. The frequency of serotype 1 has gradually increased since 1993. Twenty two, 2, 3 and 1 among 57 specimens of "others" by EIA from Tokyo, Mainzuru, Sapporo and Kurume in 1995-1996 and 1996-1997 were determined as serotypes 1, 2, 3 and 9 by RT-PCR, respectively. (author abst.)
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