Age-related Changes in Bruch's Membrane in Rats.
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Accession number;99A0286421
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| Title;Age-related Changes in Bruch's Membrane in Rats. |
| Author;
TOKURA TAKAO
(Kansai Med. Univ.)
ITO SHIGEO
(Kansai Med. Univ.)
NISHIKAWA MUTSUHIKO
(Kansai Med. Univ.)
YAMANE ATSUSHI
(Kansai Med. Univ.)
MIKI HIROHIKO
(Kansai Med. Univ.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.103;NO.2;PAGE.77-84(1999)
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| Figure&Table&Reference;FIG.5, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We investigated rats were worth the experimental animal on the aging changes in Bruch's membrane. Methods: We did an ultramicromorphological study on the aging changes in Bruch's membrane, in male Sprauge-Dawley rats at 1,6,12 and 27 months after their birth. Results: With the aging, the basement membranes on both sides of Bruch's membrane have become thick. At 6 months of age, the basement membranes of the endothelial cells of the choriocapillaris were found to be multilayered and cracked and pseudopodia of the endothelium were also observed toward the retinal pigment epithelium. At 12 months of age, we found vacuoles in the basal portion of the retinal pigment epithelium, as well as fibrillae and a part of the process of a cell in the outer collagenous zone correspond with the portion of the multilayered and cracked basement membranes of the endothelial cells of the choriocapillaris. At the age of 27 months, the basement membranes were thicker and a basal laminar deposit was seen. Prominent changes such as disappearance of the elastic fibers and increase of the collagenous fibers and fibrillae were also seen in some portions. Conclusions: Thus, the aging changes in Bruch's membrane of rats were remarkably reinforced in accordance with the age, it were appeared these rats were worth the experimental animal. (author abst.) |
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