Preliminary Evaluation of Adjuvant Chemotherapy Against Stage Ib or II Gastric Cancer.
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Accession number;99A0286466
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| Title;Preliminary Evaluation of Adjuvant Chemotherapy Against Stage Ib or II Gastric Cancer. |
| Author;
INADA TAKAO
(Tochigi Cancer Center)
KAWAKUBO HIROFUMI
(Tochigi Cancer Center)
ICHIKAWA AKIRA
(Tochigi Cancer Center)
OGATA YOSHIRO
(Tochigi Cancer Center)
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Journal Title;Japanese Journal of Cancer and Chemotherapy
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Journal Code:Z0938A
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ISSN:0385-0684
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VOL.26;NO.3;PAGE.315-320(1999)
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| Figure&Table&Reference;FIG.5, TBL.2, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The prognostic influence of post-operative adjuvant chemotherapy on stage Ib or II gastric cancer was studied retrospectively. The immunohistochemical expressions of p53 protein and thymidine phosphorylase(TP) were also examined; the relations between these protein expressions and clinicopathological features along with the effect of adjuvant chemotherapy were also investigated. The 5-year survival rate of the patients who received adjuvant chemotherapy was 95.5%, which was better than that(89.8%) of those who did not, although the difference did not reach significance(p=0.09). The venous invasion of tumor was slight frequently observed in p53 or TP positive cases than negative cases, respectively(p<0.1), but no significant associations were found between the t-, n- or ly-factor, and p53 or TP expression. Moreover p53 and TP expression had no significant influence on post-operative survival. But, among the patients with p53- or TP-positive tumor, adjuvant chemotherapy conferred survival benefits, although the difference did not reach significance. The 5-year survival rate was 100% with adjuvant chemotherapy, 84.3% without chemotherapy in p53-positive patients(p=0.137), 97.0% with adjuvant chemotherapy, and 90.8% without chemotherapy in TP-positive tumors(p=0.326). (author abst.) |
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