Science Links Japan | A Case of Hepatocellular Carcinoma with Tumor Thrombus in the Right Atrium Successfully Treated by Arterial Administration of Lipiodol-Smancs.

A Case of Hepatocellular Carcinoma with Tumor Thrombus in the Right Atrium Successfully Treated by Arterial Administration of Lipiodol-Smancs.

Accession number;99A0286473

Title;A Case of Hepatocellular Carcinoma with Tumor Thrombus in the Right Atrium Successfully Treated by Arterial Administration of Lipiodol-Smancs.

Author; YAMADA KATSUYUKI (Osaka-shiritsu Sogo Iryo Senta) SATO TOSHIHIKO (Osaka-shiritsu Sogo Iryo Senta) YAMADA ATSUKO (Osaka-shiritsu Sogo Iryo Senta) TANAKA SHIRO (Osaka-shiritsu Sogo Iryo Senta) FUJII SATORU (Osaka-shiritsu Sogo Iryo Senta) MATSUO RYOICHI (Osaka-shiritsu Sogo Iryo Senta) MURATA KATSUKO (Osaka-shiritsu Sogo Iryo Senta) MANABE TAKAO (Osaka-shiritsu Sogo Iryo Senta) ODA JUNRO (Osaka-shiritsu Sogo Iryo Senta)

Journal Title;Japanese Journal of Cancer and Chemotherapy

Journal Code:Z0938A

ISSN:0385-0684

VOL.26;NO.3;PAGE.361-364(1999)

Figure&Table&Reference;FIG.2, REF.5

Pub. Country;Japan

Language;Japanese

Abstract;In February, 1996, a 73-year-old male with liver dysfunction was admitted to our hospital for further examination and treatment of liver tumor. The liver tumor was revealed by imaging examination, which was mainly in the S4-S8 of liver with a thrombus growing from the right anterior branch to the right branch of the portal vein, and from the right hepatic vein to the inferior vena cava and right atrium. The serum AFP and PIVKA-II levels were elevated to 3.610ng/ml and 54AU/ml, respectively. The patient was diagnosed as having hapatocellular carcinoma, and was treated by arterial administration of anticancer drugs(epirubicin hydrochloride, mitomycin C and carboplatin) and TAE. Though the main tumor(S4-S8 of liver) was reduced by TAE, the portal and atrial tumor thrombus did not respond. One month after TAE(20 May, 1996), the first arterial administration of Lipiodol-SMANCS was given, followed by 4 successive procedures with an interval of about 1.5 months(total dose 15mg), resulting in remarkable tumor thrombus shrinkage and reduction of AFP levels to 80ng/ml. This case shows that arterial administration of SMANCS may be one of the effective treatments for hepatocellular carcinoma, even with tumor thrombus of hepatic vein, IVC and right atrium. (author abst.)

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