A Case of Advanced Gall Bladder Cancer Responding to Neoadjuvant Intra-arterial Chemotherapy.

Accession number;99A0286474
Title;A Case of Advanced Gall Bladder Cancer Responding to Neoadjuvant Intra-arterial Chemotherapy.
Author; KAWABATA YASUNARI (Shimane Med. Univ.) YANO SEIJI (Shimane Med. Univ.) OISHI TATSURO (Shimane Med. Univ.) SUMI SHOICHIRO (Shimane Med. Univ.) NIO YOSHINORI (Shimane Med. Univ.) TAMURA KATSUHIRO (Shimane Med. Univ.)
Journal Title;Japanese Journal of Cancer and Chemotherapy
Journal Code:Z0938A
ISSN:0385-0684
VOL.26;NO.3;PAGE.365-368(1999)
Figure&Table&Reference;FIG.4, REF.9
Pub. Country;Japan
Language;Japanese
Abstract;The patient was a 52-year-old female who had been diagnosed as advanced gall bladder cancer by various imaging studies. The cancer responded to neoadjuvant intra-arterial chemotherapy and was curatively resected. Since cancer had invaded the median widely, the posterior and the lateral segments of the liver according to CT imaging, neoadjuvant chemotherapy was used. The combination chemotherapy included intra-arterial chemotherapy(CDDP 10mg+5-FU 250mg/day/week*5 times, EPI 10mg+5-FU 250mg/day/week*3 times) through the hepatic artery and oral chemotherapy(UFT 300mg/day for 106 days). No severe side effects were found during this chemotherapy. Imaging studies after the chemotherapy showed a partial response(PR) and curative resection(hepato-pancreato-duodenectomy with regional lymphnodes dissection) could be performed successfully. She has been disease-free without any sign of recurrence for 18 months after surgery. We conclude that this combination chemotherapy will be useful for advanced gall bladder cancer if the appropriate combinations, dosages, and administration routes are chosen. (author abst.)