Science Links Japan | A Case of Pleural and Mediastinal Lymph Node Metastases from Breast Cancer Effectively Treated with Fadrozole Hydrochloride in Combination with Cyclophosphamide.

A Case of Pleural and Mediastinal Lymph Node Metastases from Breast Cancer Effectively Treated with Fadrozole Hydrochloride in Combination with Cyclophosphamide.

Accession number;99A0286477

Title;A Case of Pleural and Mediastinal Lymph Node Metastases from Breast Cancer Effectively Treated with Fadrozole Hydrochloride in Combination with Cyclophosphamide.

Author; KOKUFU IKUO (Itami City Hosp.) FUKUDA KAZUHIRO (Itami City Hosp.) YAMAMOTO MASAYUKI (Itami City Hosp.) YANO TOKIHARU (Itami City Hosp.) YAMADA KATSUMI (Itami City Hosp.) KITANO HIDETAKE (Itami City Hosp.) KIM Y-H (Itami City Hosp.) PENG Y-F (Itami City Hosp.)

Journal Title;Japanese Journal of Cancer and Chemotherapy

Journal Code:Z0938A

ISSN:0385-0684

VOL.26;NO.3;PAGE.377-379(1999)

Figure&Table&Reference;FIG.3, REF.8

Pub. Country;Japan

Language;Japanese

Abstract;A 63-year-old woman was diagnosed with pleural and mediastinal lymph node metastases 116 months after operation because of bilateral breast cancer. She was then treated with fadrozole hydrochloride(FH)(2mg). Adriamycin(30mg) administration into the pleural cavity was attempted, but did not prove effective. Thus, we tried to combine FH with cyclophosphamide(100mg). After one month, chemoendocrine therapy relieved her complaints of cough and shortness of breath. CT revealed a remarkable decrease of pleural effusion and disappearance of mediastinal lymph nodes. She was alive 9 months after the treatment. Fadrozole hydrochloride in combination with cyclophosphamide is promising as an effective treatment in postmenopausal patients. (author abst.)

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