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Accession number;99A0315568
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| Title;Evaluation of Effect of Seratrodast on Nasal Passage Patency in Perennial Allergic Rhinitis by Acoustic Rhinometry. |
| Author;
SAKAKURA YASUO
(Mie Univ., Sch. of Med.)
UNNO TOKUJI
(Asahikawa Med. Coll.)
ICHIMURA KEIICHI
(Univ. of Tokyo, Fac. of Med.)
KASE YASUHIRO
(Univ. of Tokyo, Univ. Branch Hosp.)
UKAI KOTARO
(Mie Univ., Sch. of Med.)
YAMAGIWA MIKIKAZU
(Mieken Koseiren Matsusaka Central Hosp.)
NONAKA SATOSHI
(Asahikawa Med. Coll.)
FUJITA TAKETOSHI
(Asahikawa Med. Coll.)
FUJITA KEN'ICHIRO
(Mieken Koseiren Matsusaka Central Hosp.)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.15;NO.2;PAGE.183-211(1999)
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| Figure&Table&Reference;FIG.7, TBL.26, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Seratrodast at 20mg/day or 80mg/day was given orally once daily after the evening meal to 38 patients with perennial allergic rhinitis to determine its effect on nasal passage patency as measured by an acoustic rhinometry. 1) In the 80mg/day group, changing rates of nasal volume and minimum cross section showed significant improvement 4 weeks after the beginning of administration as compared with baseline data. 2) Improvement rate in nasal obstruction in the 80mg/day group was higher than that in the 20mg/day group. Correlation among evaluation of improvement by symptoms, change in nasal volume and maximum cross section before and after administration and changing rates was examined. The absolute values of correlation factor were smaller than 0.5, showing no strong correlation. On the other hand, correlation with nasal obstruction was relatively higher among nasal obstruction, nasal discharge, and paroxysmal sneezing. 3) No clinically significant side effects were found in any subjects in the 20 or 80mg/day group. (author abst.) |
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