Four-week Intravenous Toxicity Study on Amrubicin Hydrochloride(SM-5887) in Rats.
|
Accession number;99A0241085
|
| Title;Four-week Intravenous Toxicity Study on Amrubicin Hydrochloride(SM-5887) in Rats. |
| Author;
ADACHI HARUHIKO
(Sumitomo Chemical Co., Ltd.)
NAKAYAMA ATSUMI
(Sumitomo Chemical Co., Ltd.)
HORII KAZUNARI
(Sumitomo Chemical Co., Ltd.)
OZAKI MASAKAZU
(Sumitomo Chemical Co., Ltd.)
INOUE TADASHI
(Sumitomo Chemical Co., Ltd.)
KAWASAKI HAJIME
(Sumitomo Chemical Co., Ltd.)
HOSOKAWA SHUNJI
(Sumitomo Chemical Co., Ltd.)
|
Journal Title;Japanese Pharmacology & Therapeutics
|
Journal Code:Z0947A
|
ISSN:0386-3603
|
|
VOL.27;NO.Suppl.1;PAGE.S.63-S.89(1999)
|
| Figure&Table&Reference;FIG.11, TBL.9, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;SM-5887 was administered intravenously to Sprague-Dawley rats for 4 weeks at dosages of 0.05, 0.15 and 0.5mg/kg to evaluate its subacute toxicity. After the 4-week treatment, some animals in each group were allowed a three-month, undosed, withdrawal period to evaluate its reversibility of any change. Control animals were given citrate phosphate buffered saline. There were no deaths during the study. No treatment-related changes were noted in clinical signs, body weights, food consumption, ophthalmology, urinalysis, blood biochemical examinations, or electro-microscopic examinations for the liver, kidney or heart. The following treatment-related changes were detected in this study. At the end of the treatment period, a decrease in lymphocyte counts was noted for males and females given 0.5mg/kg, increased incidences of small thymus and/or decreased thymus weights were noted for males given 0.15mg/kg or more and females given 0.5mg/kg. Histopathological examinations revealed slight decrease in cortical small lymphocytes in the thymus for males given 0.15mg/kg, and mild to severe decreases in cortical small lymphocytes and increases in large lymphocytes for males and females given 0.5mg/kg. In the hematological examination, a slight increase in mean corpuscular volume was noted for males given 0.5mg/kg and slight decreases in hemoglobin concentration and hematocrit value were noted for females given 0.5mg/kg. Additionally, the weight of the testes was slightly reduced in males given 0.15mg/kg or more, however, no treatment-related changes were detected in the histopathological examination. The changes observed at the end of the treatment period had recovered or tended to recover after the three-month withdrawal period.... (author abst.) |
|
|
|
Related Articles;
|
|
