Micronucleus Test on Amrubicin Hydrochloride(SM-5887) in CD-1 Mice.
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Accession number;99A0241099
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| Title;Micronucleus Test on Amrubicin Hydrochloride(SM-5887) in CD-1 Mice. |
| Author;
HARA MASAKI
(Sumitomo Chemical Co., Ltd.)
OTA MIKA
(Sumitomo Chemical Co., Ltd.)
ODAWARA KYOKO
(Sumitomo Chemical Co., Ltd.)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.27;NO.Suppl.1;PAGE.S.509-S.512(1999)
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| Figure&Table&Reference;TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Amrubicin hydrochloride(SM-5887) was examined for its potential to induce micronuclei in bone marrow cells of male mice. Eight-week-old male mice of CD-1 strain were used in a micronucleus test, and each group consisted of 5 animals. SM-5887 was administered to mice at single intrepenetrial doses of 0.5, 1,2,5 and 10mg/kg, and bone marrow smears were made 24 hours after administration. The test material induced dose-related and significant increases in the incidence of micronucleated polychromatic erythrocytes(MNPCEs) in mice. A positive control chemical, mitomycin C(1mg/kg, ip, 24 hours), induced marked increases in the incidence of micronuclei. From the above findings, it is concluded that SM-5887 has a potential to induce micronuclei in mouse bone marrow cells under the conditions tested. (author abst.) |
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