Studies on the Metabolic Fate of Amrubicin Hydrochloride(SM-5887), a Novel Antitumor Agent (7)-Effect of SM-5887 on Drug Metabolizing Enzyme System in Rats.
|
Accession number;99A0241103
|
| Title;Studies on the Metabolic Fate of Amrubicin Hydrochloride(SM-5887), a Novel Antitumor Agent (7)-Effect of SM-5887 on Drug Metabolizing Enzyme System in Rats. |
| Author;
NAKAI SHUNJI
(Sumitomo Chemical Co., Ltd.)
ITO MASAKI
(Sumitomo Chemical Co., Ltd.)
KANAMARU HIROSHI
(Sumitomo Chemical Co., Ltd.)
NAKATSUKA IWAO
(Sumitomo Chemical Co., Ltd.)
|
Journal Title;Japanese Pharmacology & Therapeutics
|
Journal Code:Z0947A
|
ISSN:0386-3603
|
|
VOL.27;NO.Suppl.1;PAGE.S.545-S.550(1999)
|
| Figure&Table&Reference;FIG.1, TBL.2, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effects of SM-5887 on the hepatic drug metabolizing enzyme system were studied after single and repeated(5 times) intravenous administrations of SM-5887 to rats at doses of 2 and 10mg/kg in single dosing, or 0.2 and 2mg/kg/day in repeated dosing. 1) After a single administration, significant increases were observed in liver weight and microsomal protein content at a dose of 10mg/kg. Slight changes were observed in aniline hydroxylase and aminopyrine N-demethylase activities, but these changes on the enzyme activities were no more remarkable than those observed after administrations of phenobarbital sodium(positive control). 2) After repeated administrations, no statistically significant changes on any item were observed. In conclusion, SM-5887 did not substantially affect the hepatic drug-metabolizing system because no significant change was observed after repeated administrations, although there were slight changes after a single administration. (author abst.) |
|
|
|
Related Articles;
|
|
