Effect of Dihydropyridine Calcium-Channel Blockers on the Plasma Carvedilol Level Following Simultaneous Administration in Rats.
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Accession number;99A0252928
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| Title;Effect of Dihydropyridine Calcium-Channel Blockers on the Plasma Carvedilol Level Following Simultaneous Administration in Rats. |
| Author;
HOKAMA NOBUO
(Univ. of Ryukyus, Sch. of Med., Hosp.)
HOBARA NORIO
(Univ. of Ryukyus, Sch. of Med., Hosp.)
KAMEYA HIROMASA
(Univ. of Ryukyus, Sch. of Med., Hosp.)
OSHIRO SUSUMU
(Univ. of Ryukyus, Sch. of Med., Hosp.)
SAKANASHI MATAO
(Univ. of Ryukyus, Fac. of Med.)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.25;NO.1;PAGE.1-7(1999)
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| Figure&Table&Reference;FIG.3, TBL.3, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The purpose of the present study was to evaluate the pharmacokinetic interaction in rats between carvedilol and three kinds of dihydropyridine calcium-channel blockers, including nicaldipine hydrochloride, nifedipine and felodipine by high-performance inquid chromatography using a solid phase extraction column. The plasma crvedilol concentrations were found to be significantly higher than the control levels at 30min-24hr and 3-8hr after the simultaneous administration of 20mg/kg carvedilol and 40mg/kg nicaldipine hydrochloride and 40mg/kg nifedipine respectively. In addition, the drug pharmacokinetic parameters, comprising the area under the concentration-time curve up to 24 hours(AUC0-24), were 6.7 and 3.0 times higher after the administration of both carvedilol and nicaldipine hydrochloride and nifedipine, respectively. In contrast, after the administration of carvedilol and 5mg/kg felodipine, the AUC0-24 showed no change. These changes are though to be attributable to either the vasodilator-induced changes in the hepatic first-pass metabolism or the metabolic inhibition. (author abst.) |
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