A Case of Hepatic Failure Due to the Administration of Warfarin.
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Accession number;99A0252937
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| Title;A Case of Hepatic Failure Due to the Administration of Warfarin. |
| Author;
HASHIMOTO HIROSHI
(National Cardiovascular Center)
UENO KAZUYUKI
(National Cardiovascular Center)
HIRAKI KIYOKAZU
(National Cardiovascular Center)
TAKADA MITSUTAKA
(National Cardiovascular Center)
MATSUO HIROSHI
(National Cardiovascular Center)
SHIBAKAWA MASAHIKO
(National Cardiovascular Center)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.25;NO.1;PAGE.60-64(1999)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 61-year-old woman weighting 57.9kg was hospitalized with deep vein thrombosis. She received warfarin therapy. At first 2mg/day of warfarin was administered for five days while from the 6th day the dose was increased to 3mg/day. From the 8th day the dose was increased to 4mg/day. Although the GOT and GPT value was within the normal range before the warfarin therapy was started, on the 5th day after the therapy was started the GOT and GPT levels were 68 and 61Iu/1, respectively, while on the 12th day the GOT and GPT had increased even more (99 and 212). We consider such hepatic evidence to be due to the administration of warfarin and its administration was thus stopped. On the 4th day after warfarin was stopped the GOT and GPT levels decreased to 55 and 128, respectively, and after that it decreased even more. Both the GOT and GPT decreased to the normal range within one month. On the other hand, in order to evaluate an allergy to warfarin, a patch test of warfarin was examined, however, the results of the test was negative. No reports of hepatic failure due to the administration of warfarin could be found on Medline from 1966 to February 1998. These results suggest this case to be a very rare one, however, further study is called for in the future. (author abst.) |
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