Studies on the Stability of Polymyxin B Sulfate Solutions and on Their Shelf-lives.
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Accession number;99A0252941
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| Title;Studies on the Stability of Polymyxin B Sulfate Solutions and on Their Shelf-lives. |
| Author;
SHIOTSU KAZUNORI
(Kumamoto Univ., Univ. Hosp.)
TANOUE NAOMI
(Kumamoto Univ., Univ. Hosp.)
NAKAMURA KAZUMI
(Kumamoto Univ., Univ. Hosp.)
KUBOTA MIHO
(Kumamoto Univ., Univ. Hosp.)
TSURUTA SATOSHI
(Kumamoto Univ., Univ. Hosp.)
ARIMORI KAZUHIKO
(Kumamoto Univ., Univ. Hosp.)
NAKANO MASAHIRO
(Kumamoto Univ., Univ. Hosp.)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.25;NO.1;PAGE.82-87(1999)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We examined the changes in potency of polymyxin B sulfate(PL-B) solution on the following two factors, the concentrations of PL-B solution and sterilization methods of PL-B solution. The treatment with a filter (0.22.MU.m) lowered the potency to 97-98% at concentrations of 1,000, 3,000 and 5,000 units/mL of PL-B solutions immediately after filtration and the potency remained unchanged until 3 months. Treatments using an autoclave markedly lowered the potency to 70.0%, 76.6% and 84.0% at concentrations of 1,000, 3,000 and 5,000 units/mL of PL-B solutions immediately after autoclaving at 115.DEG.C. and 0.7kg/cm2 for 30min, respectively. No subsequent decreases in the PL-B potency with sterilization by autoclaving were observed during the 3-month period. (author abst.) |
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