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Accession number;99A0390131
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| Title;Comparison with Indocyanine Green Angiography and Immunohistochemical Study of Choroidal Neovascular Membrane in Age-related Macular Degeneration. |
| Author;
NAKAJIMA MASAMI
(Nihondai I Inatoribyoin)
SHIMADA HIROYUKI
(Nihon Univ., Surugadai Hosp.)
SATO MISAO
(Nihon Univ., Surugadai Hosp.)
YUZAWA MITSUKO
(Nihon Univ., Surugadai Hosp.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.103;NO.3;PAGE.252-258(1999)
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| Figure&Table&Reference;FIG.11, TBL.1, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We classified choroidal neovascular membranes(CNMs)(48 eyes) in age-related macular degeneration(AMD) into four types using indocyanine green angiography. Methods: Surgically extracted CNMs were examined immunohistochemically. Specimens were stained with glial fibrillary acidic protein(GFAP), von Willebrand factor, Ki-67 antigen, actin, vascular endothelial growth factor(VEGF), basic fibroblast growth factor(b-FGF), and transforming growth factor(TGF-.BETA.1). Results: All types of CNM were positively stained with GFAP on the side opposite the retinal pigment epithelial(RPE) cells. This suggests the adherence of neurosensory retina to the CNM. Type I membranes which showed hyperfluorescence in the early and late phase of ICG angiography were significantly stained with Ki-67 antigen. Conclution: These results indicate that CNMs in AMD are extracted with neurosensory retina and RPE cells during surgery. Type I membranes have a high capability for proliferation. (author abst.) |
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