Vibrio vulnificus Infection: Clinical and Bacteriological Analysis of Four Cases.
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Accession number;99A0385875
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| Title;Vibrio vulnificus Infection: Clinical and Bacteriological Analysis of Four Cases. |
| Author;
ITO ISAO
(Kurashiki Cent. Hosp.)
OSAWA MAKOTO
(Kurashiki Cent. Hosp.)
ARITA MACHIKO
(Kurashiki Cent. Hosp.)
HASHIMOTO TOORU
(Kurashiki Cent. Hosp.)
ISHIDA TADASHI
(Kurashiki Cent. Hosp.)
HONGO TOSHIHARU
(Kurashiki Cent. Hosp.)
FUJII HIROYUKI
(Kurashiki Cent. Hosp.)
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Journal Title;Journal of the Japanese Association for Infectious Diseases
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Journal Code:Z0760A
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ISSN:0387-5911
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VOL.73;NO.2;PAGE.149-154(1999)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Vibrio vulnificus(V. vulnificus) infection has recently been drawning attention as a high mortality disease especially in a patient with the preexisting chronic liver disease. The illness casued by V. vulnificus is divided into three groups such as primary septicemia, wound infection and gastrointestinal illness. Primary septicemia, which is the most common in Japan, is defined as a systemic illness presenting fever or hypotension with recovery of V. vulnificus from blood or tissue without the apparent primary focus of infection. We diagnosed four cases as infectious diseases of V. vulnificus by isolating it from each clinical material in Kurashiki Central Hospital from 1984 through 1997. We investigated clinical manifestations of the four cases including season of the onset, presence of drinking habit, underlying diseases, consumption of raw seafood, symptoms, presence of disseminated intravascular coagulation(DIC) or shock, laboratory data, administered antibiotics and the outcomes of the treatment. And for each strain, we also performed in vitro drug susceptibility tests. The age of the patients ranged from 49 to 61 years old (mean 56), and all of the patients were male. Each of them had a chronic liver disease as an underlying disease. Two of them had a history of raw seafood consumption prior to the onset of the illness. Skin manifestations appeared in two of the four patients. All the patients complicated septic shock and DIC. V. vulnificus was isolated from the venous blood cultures of them. Three of the four were given a diagnosis of primary septicemia and one was made a diagnosis of acute cholecystitis which has never been reported previously. Three of the four patients died and only the rest was alive as a result of antimicrobial therapy. In the sensitivity tests, the four strains were revealed to be very sensitive to the antimicrobials such as minocycline, cephalosporins of the third generation and carbapenems.... (author abst.) |
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