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Accession number;99A0412426
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| Title;Hypotriglyceridemic Effect of Globin Digest on Subjects with Borderline Hyperlipidemia. |
| Author;
KAGAWA KYOICHI
(Hankyukyoeibussan Yakuriken)
FUKUHAMA CHIZUKO
(Hankyukyoeibussan Yakuriken)
FUJINO HIROAKI
(Hankyukyoeibussan Yakuriken)
OKUDA HIROMICHI
(Ehime Univ., Sch. of Med.)
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Journal Title;Journal of Japanese Society of Nutrition and Food Science
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Journal Code:F0624A
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ISSN:0287-3516
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VOL.52;NO.2;PAGE.71-77(1999)
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| Figure&Table&Reference;FIG.5, TBL.3, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It has already been reported that globin digest (GD) exerts a hypotriglyceridemic action in laboratory animals and humans. A tetrapeptide, Val-Val-Tyr-Pro, extracted from GD, has also been shown to be 7000-times more active than the parent GD. We studied the hypotriglyceridemic effect of GD in subjects with borderline hyperlipidemia. In normal subjects, 1 g of GD showed sufficient hypotriglyceridemic action. When borderline hypertriglyceridemic subjects were administered 1 g of GD as a beverage with 40 g of fat, the increases in serum and chylomicron (CM) TGs at 1-5 h after the administration were suppressed to 25-50% of the control values (without GD). The areas under the serum TG and CM-TG concentration curves (AUCs; 0-6 h) were significantly decreased to about 40% of the control, respectively. GD enhanced the elimination rate constants of TG and CM-TG in borderline hypertriglyceridemic subjects, and showed a more effective hypotriglyceridemic action than in normal subjects. GD thus appears to be useful for prevention of cardiovascular disease and atherosclerosis in subjects with borderline hypertriglyceridemia. (author abst.) |
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