Glucose Transporter 4 (GLUT4) mRNA Abundance in the Adipose Tissue and Skeletal-Muscle Tissue of Ovariectomized Rats Treated with 17.BETA.-Estradiol or Progesterone.
|
Accession number;99A0225421
|
| Title;Glucose Transporter 4 (GLUT4) mRNA Abundance in the Adipose Tissue and Skeletal-Muscle Tissue of Ovariectomized Rats Treated with 17.BETA.-Estradiol or Progesterone. |
| Author;
SUGAYA A
(Mie Univ. School Of Medicine, Mie, Jpn)
SUGIYAMA T
(Mie Univ. School Of Medicine, Mie, Jpn)
YANASE S
(Mie Univ. School Of Medicine, Mie, Jpn)
TERADA Y
(Mie Univ. School Of Medicine, Mie, Jpn)
TOYODA N
(Mie Univ. School Of Medicine, Mie, Jpn)
|
Journal Title;J Obstet Gynaecol Res
|
Journal Code:Y0696A
|
ISSN:1341-8076
|
|
VOL.25;NO.1;PAGE.9-14(1999)
|
| Figure&Table&Reference;FIG.2, TBL.2, REF.23 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: To investigate the effects of 17.BETA.-estradiol and progesterone on the expression of glucose transporter 4 (GLUT4) in the adipose tissue and skeletal-muscle tissue of ovariectomized rats.Methods: Female Sprague-Dawley rats (n = 63) received a daily subcutaneous injection of 10 .MU.g, 50 .MU.g, or 250 .MU.g of 17.BETA.-estradiol (Group E) or of 1 mg, 5 mg or 25 mg of progesterone (Group P) for 3 days, 7 days, or 10 days (n = 3, at each dose). The expression of GLUT4 mRNA was assessed by performing ribonuclease protection assays. Results: The levels of GLUT4 mRNA in adipose tissue was significantly reduced by treatment with estradiol, 50 .MU.g or 250 .MU.g, relative to findings in control rats (p < 0.01). No such reductions were seen regarding the progesterone treatment. The level of GLUT4 mRNA in skeletal-muscle tissue did not change, regardless of treatment. Conclusion: In ovariectomized rats, higher than physiologic dosages of 17.BETA.-estradiol can suppress the expression of GLUT4 mRNA in adipose tissue. (author abst.) |
|
|
|
Related Articles;
|
|
|
