Clinical Experiment of High-Dose Chemotherapy with Autologous Blood Stem Cell Transplantation in the Treatment of Advanced Testicular Tumor.
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Accession number;99A0233525
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| Title;Clinical Experiment of High-Dose Chemotherapy with Autologous Blood Stem Cell Transplantation in the Treatment of Advanced Testicular Tumor. |
| Author;
NAKAMURA MOTONOBU
(Kyushu Univ., Fac. of Med.)
NAITO SEIJI
(Kyushu Univ., Fac. of Med.)
MOCHIDA OSAMU
(Kyushu Univ., Fac. of Med.)
NAKASHIMA MICHITAKA
(Kyushu Univ., Fac. of Med.)
KUMAZAWA JOICHI
(Kyushu Univ., Fac. of Med.)
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Journal Title;Nishinihon Journal of Urology
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Journal Code:Z0253B
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ISSN:0029-0726
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VOL.61;NO.1;PAGE.27-30(1999)
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| Figure&Table&Reference;TBL.4, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;High-dose chemotherapy supported with autologous peripheral blood stem cell transplantation(PBSCT) was administered to three patients with advanced germ cell tumors which were resistant to cisplatin-based chemotherapy. Sufficient peripheral blood stem cell were collected by administration of VP-16 1,500mg-2,000mg/m2 and G-CSF. High-dose chemotherapy consisted of CBDCA 1,250-1,500mg/m2, VP-16 1,500mg/m2 and CPA 120mg/kg or IFM 7.5g/m2. One patient achieved surgical complete response, but this continued only for three months. The other patients had progressive disease. Leukocyte recovery with PBSCT and G-CSF took 7 to 10 days and severe nonhematologic toxicity was not observed. High-dose chemotherapy with PBSCT is well tolerated and might be potentially curative salvage chemotherapy for germ cell tumors which are resistant to induction chemotherapy. (author abst.) |
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