The combined analgesic effects of neurotropin and amitriptyline in SART-stressed mice.
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Accession number;99A0334523
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| Title;The combined analgesic effects of neurotropin and amitriptyline in SART-stressed mice. |
| Author;
MIURA TOMOO
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
YOSHIDA HIROYUKI
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
KAGEYAMA KEN'ICHI
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
NAMBA HIROYOSHI
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
KOGA YURYU
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
IENAGA KAZUHARU
(Nippon Zoki Pharm. Co., Ltd., Inst. of Bio-Active Sci.)
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Journal Title;Medical Consultation & New Remedies
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Journal Code:Z0942A
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ISSN:0037-380X
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VOL.36;NO.1;PAGE.47-53(1999)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We evaluated the combined analgesic effects of neurotropin and amitriptyline in SART-stressed mice which show hyperalgesia. 1. The analgesic ED50 values of single oral administrations of neurotropin and amitriptyline were 194NU/kg and 37mg/kg, respectively. 2. The combination dosages of neurotropin and amitriptyline were computed according to Gaddum's theory. In one of combinations, theoretical ED50 values(theoretical value A), [1/3ED50 neurotropin+2/3ED50 amitriptyline] was [64.7NU/kg neurotropin+24.7mg/kg amitriptyline]. In another combination, [2/3ED50 neurotropin+1/3ED50 amitriptyline] was [129.3NU/kg neurotropin+12.3mg/kg amitriptyline]. 3. Actually, We examined the combined administration with neurotropin and amitriptyline. One of two combinations of experimental ED50 values(experimental value B), [1/3ED50 neurotropin+2/3ED50 amitriptyline] was [44.8NU/kg neurotropin+17.1mg/kg amitriptyline]. Another one of combinations, [2/3ED50 neurotropin+1/3ED50 amitriptyline] was [110.3NU/kg neurotropin+10.5mg/kg amitriptyline]. 4. We calculated the ratio of theoretical value A and experimental value B, and evaluated the combined analgesic effects. In the case of [1/3ED50 neurotropin+2/3ED50 amitriptyline], B/A ratio was indicated 0.69. And in the case of [2/3ED50 neurotropin+1/3ED50 amitriptyline], B/A ratio was indicated 0.85. In both cases, B/A ratios were less than one. The combined analgesic effects of neurotropin and amitriptyline was at least more than the additional effect, because of B/A<1. (author abst.) |
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