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Accession number;99A0450362
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| Title;The Effect of Lymphocytapheresis on Multiple Screlosis. |
| Author;
MUNAKATA REIKO
(Morioka Red Cross Hosp.)
UTSUGISAWA KIMIAKI
(Iwate Med. Univ.)
NAGANE YURIKO
(Iwate Med. Univ.)
UKITSU MIYUKI
(Iwate Med. Univ.)
TOGI HIDEO
(Iwate Med. Univ.)
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Journal Title;Brain Nerve
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Journal Code:Z0685A
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ISSN:0006-8969
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VOL.51;NO.3;PAGE.235-239(1999)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.27 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We studied the effect of lymphocytapheresis(LCP) on the expanded disability status scale(EDSS) clinical score, lymphocyte subsets and Interleukin-2(IL-2) production by peripheral blood mononuclear cell(PBM) in 5 patients with multiple screlosis(MS). The EDSS clinical score significantly decreased after LCPs(p<0.05). PBM IL-2 production and CD4/8 ratio significantly decreased(p<0.05, p<0.05), and the number of neutrocytes and CD11b+CD8+(%) significantly increased immediately after LCP(p<0.05, p<0.05). Down-regulation of PBM IL-2 production and CD4/8 ratio and up-regulation of CD11b+CD8+ may account for therapeutic effect of LCP on MS. However, similar changes were observed in patients with CIDP and MG during immunoadsorbent therapy(IAT). It is possible that down-regulation of PBM IL-2 production and CD4/8 ratio and up-regulation of CD11b+CD8+ and the number of neutrocytes may commonly result from apheresis therapy using extracorporeal circulation. (author abst.) |
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