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Accession number;99A0460687
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| Title;Effect of Mitomycin C Dissolved in a Reversible Thermosetting Gel on Outcome of Filtering Surgery in the Rabbit. |
| Author;
ICHIEN KOJI
(Gifu Univ., Sch. of Med.)
SAWADA AKIRA
(Gifu Univ., Sch. of Med.)
YAMAMOTO TETSUYA
(Gifu Univ., Sch. of Med.)
KITAZAWA YOSHIAKI
(Gifu Univ., Sch. of Med.)
SHIRAKI REIKO
(Gifu Univ., Sch. of Med.)
YO MUTSUYOSHI
(Gifu Univ., Sch. of Med.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.103;NO.4;PAGE.277-281(1999)
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| Figure&Table&Reference;FIG.5, TBL.2, REF.32 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: Based on our previous report that showed enhanced transfer of mitomycin C to the sclera and the conjunctiva by dissolving the antiproliferative in a reversible thermo-setting gel, we conducted a study to investigated the efficacy of the mitomycin C-gel in the rabbit. Methods: We subconjunctivally injected 0.1ml of the mitomycin C-gel solution containing several amounts of the drug. Trephination was performed in the injected region 24 hours later. Intraocular pressure measurement, and photography and ultrasound biomicroscopic examination of the filteringbleb were done 1, 2, and 4 weeks postoperatively. Results: The gel containing 3.0.MU.g or more mitomycin C significantly enhanced bleb formation in addition to reducing the intraocular pressure. Conclusion: The reversible thermo-setting gel seems to facilitate filtration following glaucoma filtering surgery in the rabbit and deserves further investigation as a new method of mitomycin C application. (author abst.) |
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