Endothelial-Derived Nitric Oxide Mediates the Peripheral Vasodilatory Effects of Amrinone in Humans.
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Accession number;99A0217963
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| Title;Endothelial-Derived Nitric Oxide Mediates the Peripheral Vasodilatory Effects of Amrinone in Humans. |
| Author;
SAKANE TAKESHI
(Shimane Med. Univ.)
ISHIBASHI YUTAKA
(Shimane Med. Univ.)
SHIMADA TOSHIO
(Shimane Med. Univ.)
INOUE SHIN'ICHI
(Shimane Med. Univ.)
SUGAMORI TAKASHI
(Shimane Med. Univ.)
HIRANO YOSHIFUMI
(Shimane Med. Univ.)
TAKAHASHI NOBUYUKI
(Shimane Med. Univ.)
MURAKAMI YO
(Shimane Med. Univ.)
MURAKAMI RINJI
(Shimane Med. Univ.)
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Journal Title;J Cardiol
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Journal Code:Y0264A
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ISSN:0914-5087
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VOL.33;NO.1;PAGE.13-19(1999)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Amrinone, which is used for the treatment of acute congestive heart failure, has vasodilatory and positive inotropic effects through the increment of intracellular cyclic adenosine monophosphate. Recent in vitro investigations have shown that amrinone has an endothelium-dependent vasodilatory effect. The present study examined whether amrinone shows this endothelium-dependent vasodilatory effect in human peripheral vessels. Forearm blood flow during intra-arterial infusion of graded doses(12.5,25,50,100,200.MU.g/min) of amrinone was measured using plethysmography in 10 healthy subjects without organic vascular disease before and after nitric oxide synthase blocking with NG-monomethyl-L-arginine(L-NMMA, 400.MU.mol). The graded dose of amrinone produced progressive increases in amrinone plasma concentrations, and a dose over 100.MU.g/min caused amrinone plasma concentrations of more than 1.0.MU.g/ml. The increase in forearm blood flow in response to amrinone was significantly depressed after L-NMMA doses of less than 100.MU.g/min, but the increase in forearm blood flow during infusion of higher doses(100,200.MU.g/min) was not affected by L-NMMA. These results suggest that endothelial-derived nitric oxide may partially contribute to amrinone-induced vasodilation in humans. Thus, the vasodilatory effect of amrinone might be impaired in patients with endothelial dysfunction. (author abst.) |
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