Clinicopathological study of background gastric mucosa during long-term conservative maintenance therapy for intractable peptic ulcer.
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Accession number;99A0327122
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| Title;Clinicopathological study of background gastric mucosa during long-term conservative maintenance therapy for intractable peptic ulcer. |
| Author;
NIMURA H
(Jikei Univ. School Of Medicine, Tokyo, Jpn)
TAKAYAMA S
(Jikei Univ. School Of Medicine, Tokyo, Jpn)
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Journal Title;J Gastroenterol
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Journal Code:Z0748A
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ISSN:0944-1174
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VOL.34;NO.1;PAGE.18-27(1999)
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| Figure&Table&Reference;FIG.7, TBL.4, REF.43 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We studied the background gastric mucosa in eight patients with intractable peptic ulcer in whom gastric cancer developed during more than 4 years' administration of histamine (H)2-receptor antagonists (H2-RAs), and in two patients with intractable gastric ulcer without gastric cancer in whom H2-RAs were administered for 4 years. As controls, we studied background mucosa in seven patients with combined gastroduoderal ulcers not treated with H2-RAs. The cancers were differentiated adenocarcinomas in all eight patients. The characteristic features of these patients and of the two patients with intractable gastric ulcer were: expansion of the generative cell zone, poor differentiation of the goblet cells, mild cellular atypia, and abnormal branching and anastomosis of glands, as well as wide areas of incomplete-type intestinal metaplasia. The sites of the differentiated adenocarcinomas were classified by mucin histochemistry as intestinal-type mucosa in all patients. A special type of incomplete intestinal metaplasia, of the intestinal type and which retained gastric-type properties, was present in some areas, and p53-positive cells were observed in some areas. In patients with intractable gastric ulcer in whom the background gastric mucosa had been exposed to more than 4 years of H2-RA treatment, it was considered possible that the preconditions for cancerous lesions were present. (author abst.) |
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