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Accession number;99A0447119
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| Title;Epidemiological Characteristics and Virulence Factor of Verotoxin-producing Eschericia coli O121:H19 Isolated in Akita Prefecture in July 1997. |
| Author;
YATSUYANAGI JUN
(Akita Prefect. Inst. of Public Health)
KIUCHI YU
(Akita Prefect. Inst. of Public Health)
SAITO SHIOKO
(Akita Prefect. Inst. of Public Health)
SUZUKI YOKO
(Akita Prefect. Inst. of Public Health)
SATO HIROYASU
(Akita Prefect. Inst. of Public Health)
MIYAJIMA YOSHIMICHI
(Akita Prefect. Inst. of Public Health)
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Journal Title;Journal of the Japanese Association for Infectious Diseases
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Journal Code:Z0760A
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ISSN:0387-5911
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VOL.73;NO.3;PAGE.218-224(1999)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Epidemiological characteristics and virulence factors of VTEC O121:H19 strains isolated in July 1997 from a 15 year old female and a 20 year old male patient suffering from bloody diarrhea and severe abdominal pain were examined. The 2 VTEC O121:H19 isolates showed identical antibiotic susceptibility patterns, biochemical characteristics and plasmid profile while slight differences were observed in their Xba I and Not I PFGE patterns, suggesting that closely related 2 VTEC O121:H19 strains evoked the sporadic infectious cases in July 1997. The 2 VTEC O121:H19 isolates, as well as VTEC O157:H7, possessed eaeA gene and a ca.60MDa plasmid which hybridised with CVD 419 probe and produced enterohemolysin. In addition, the VETC O121:H19 isolates produced almost the same amount of VT-2 in vitro as VTEC O157:H7 did. These results suggested that VTEC O121:H19 possessed the virulence factor comparable to that of VTEC O157:H7. Incidence, molecular epidemiology and infectious source of VTEC O121:H19 in this country have not been sufficiently understood. Antiserum for E. coli serogroup O121 should be manufactured to clarify the epidemiology of the highly virulent VTEC strain. (author abst.) |
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