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Accession number;99A0447122
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| Title;Effect of Antibiotics and Antibody on Phagocytic Bactericidal Activity of Polymorphonuclear Neutrophilis of Bordetella pertussis. |
| Author;
MURAOKA HIROE
(Mitsubishi Kagaku Bio-Clinical Lab., Inc.)
AOYAMA TATSUO
(Kawasaki Munic. Kawasaki Hosp.)
SAIKA TAKESHI
(Mitsubishi Kagaku Bio-Clinical Lab., Inc.)
SATO YUMIE
(Mitsubishi Kagaku Bio-Clinical Lab., Inc.)
KOBAYASHI INTETSU
(Mitsubishi Kagaku Bio-Clinical Lab., Inc.)
AKITA HIRONOBU
(St. Marianna Univ.)
IWATA SATOSHI
(Kasumigaura National Hospital)
SATO YOSHITAKE
(Sogo Ota Byoin)
SUNAKAWA KEISUKE
(Kitasato Univ., Sch. of Med.)
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Journal Title;Journal of the Japanese Association for Infectious Diseases
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Journal Code:Z0760A
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ISSN:0387-5911
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VOL.73;NO.3;PAGE.239-243(1999)
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| Figure&Table&Reference;TBL.3, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The phagocytic bactericidal activity of the polymononucler neutrophils(PMNs) that were collected from healthy volunteer with and without antibody against Bordetella pertussis was investigated. Furthermore, these activity against B. pertussis under observing penicillins or macrolides antibiotics was investigated. Although no efficacy to B. pertussis strain by the PMNs in serum without antibody, but the viable cells of B. pertussis decreased to 1/1,000 1hr after incubation and was not detected after 4hrs. In particular, the viable cells of B. pertussis by the PMNs in serum with antibody was markedly reduced when azithromycin was present. These results suggests that the synergistic action of macrolide antibiotics and antibody-mediated phagocytic bactericidal activity on B. pertussis may have clinical relevance. (author abst.) |
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