Compatibility of Sodium Ferrous Citrate Improved-Granules in Combination with Other Preparations.
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Accession number;99A0450021
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| Title;Compatibility of Sodium Ferrous Citrate Improved-Granules in Combination with Other Preparations. |
| Author;
ARAI YOSHIHARU
(Tokai Univ., Hosp.)
NAKANE TOMOKO
(Tokai Univ., Hosp.)
KUBOTA AKIE
(Tokai Univ., Hosp.)
MIZUSHIMA NORIKO
(Tokai Univ., Hosp.)
SHIBATA TETSUICHI
(Tokai Univ., Hosp.)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.25;NO.2;PAGE.176-186(1999)
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| Figure&Table&Reference;FIG.2, TBL.5, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Sodium Ferrous Citrate formulation, Ferromia granule was originally supplied as film-coated granules. However, some problems have been pointed out with this formulation regarding awkwardness in handling and unpleasantness during consumption. Therefore, corrigent was added while the film conting was removed in order to improve it. We investigated influence of changing the formilative method, and carry out the incompatibility test and hygroscopic test on 29 powders which can be admixed together. Furthermore, we also carried out a ferrous ion dissolution test on 11 powders which are likely to have an ionic interaction with iron. As a result, the modified granuls were incompatible when combined with ascorbic acid powder, Cinal granule, sodium bicarbonate and folic acid powder(10%). The modified granules demonstrated no water-vapor sorption at 25.DEG.C., 75% RH at 30 days. Hygroscopicity was not considered to be related to incompatibility, and no noticeable difference was found due to the modification of the formulation. In the compounding the sample, dissolution property demonstrated only a slight difference in the ferrous ion elution. (author abst.) |
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