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Accession number;99A0453848
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| Title;Determination of Human Serum Albumin Using a Biosensor System Constructed with Piezoelectric Quartz Crystal. |
| Author;
OGATA SUSUMU
(Mie Univ., Fac. of Bioresour.)
OKUMURA KATSUZUMI
(Mie Univ., Fac. of Bioresour.)
TAGUCHI HIROSHI
(Mie Univ., Fac. of Bioresour.)
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Journal Title;Bull Fac Bioresour Mie Univ
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Journal Code:Y0251B
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ISSN:0915-0471
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VOL.;NO.21;PAGE.67-72(1999)
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| Figure&Table&Reference;FIG.7, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;It has been known that a small amount of serum albumin (30 .MU.g/ml) is detected in urine at the early stage of diabetes mellitus due to diabetic nephropathy and it is called microalbuminuria. First we tried to develop a biosensor system with a quartz crystal microbalance for simple and rapid detection of such serum albumin. At first, oscillation of the quartz crystal microbalance was not stable in ion-containing solutions such as urine. Then we constructed a flow cell, in which only one side of the electrodes of a piezoelectric quartz crystal is in contact with the liquid. As a result, oscillation was stable and human serum albumin (10 .MU.g/ml) was detected with the quartz crystal on which anti-human serum albumin was coated via polyethylenimine. Using this system, we can monitor microalbuminuria, conveniently and rapidly. (author abst.) |
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