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Accession number;99A0264704
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| Title;Myopathy with cerebral white matter abnormality. A case report. |
| Author;
MOCHIZUKI YOKO
(Nihon Univ., Nerima Hosp.)
OISHI MINORU
(Nihon Univ., Nerima Hosp.)
IIDA KIYOSHI
(Nihon Univ., Nerima Hosp.)
TAJIRI NOBUO
(Nihon Univ., Nerima Hosp.)
TAKASU TOSHIAKI
(Nihon Univ., Sch. of Med.)
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Journal Title;Clinical Neurology
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Journal Code:Z0689A
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ISSN:0009-918X
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VOL.38;NO.9;PAGE.811-815(1998)
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| Figure&Table&Reference;FIG.4, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 45-year-old man noticed mild numbness of the feet at the age of 40 years and difficulty in standing up from squatting position at 43 years. His birth and developmental milestones were normal and the family history was unremarkable. He was alert and intelligent with global IQ of 91. There was mild muscle weakness as well as atrophy in bilateral hips and thighs. The serum creatine kinase level was 542U/l. On computed tomography, the hamstrings were preferentially involved. The biopsied specimens from the right quadriceps femoris and peroneal muscles showed myogenic changes with evidence of necrotic and regenerating process. Dystrophin, dystrophin-associated glycoproteins and merosin were normally expressed. From the clinical and pathologic findings, he was diagnosed as having myopathy. The electroencephalogram was normal but the P300 latency was prolonged. T2-weighted head magnetic resonance imaging showed diffuse high intensity in the cerebral white matter. Myopathy with cerebral white matter abnormality in adult patients has not yet been reported. Asymptomatic cerebral white matter abnormality should be considered in adult patients with myopathy. (author abst.) |
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