Science Links Japan | Excess caloric intake induced severe hypercapnia in a patient with Duchenne muscular dystrophy on nonivansive positive pressure ventilation.

Excess caloric intake induced severe hypercapnia in a patient with Duchenne muscular dystrophy on nonivansive positive pressure ventilation.

Accession number;99A0264706

Title;Excess caloric intake induced severe hypercapnia in a patient with Duchenne muscular dystrophy on nonivansive positive pressure ventilation.

Author; MATSUMURA TSUYOSHI (National Sanatorium Toneyama Hospital) SAITO TOSHIO (National Sanatorium Toneyama Hospital) MIYAI ICHIRO (National Sanatorium Toneyama Hospital) NOZAKI SONOKO (National Sanatorium Toneyama Hospital) KANG J (National Sanatorium Toneyama Hospital)

Journal Title;Clinical Neurology

Journal Code:Z0689A

ISSN:0009-918X

VOL.38;NO.9;PAGE.822-825(1998)

Figure&Table&Reference;FIG.3, TBL.1, REF.12

Pub. Country;Japan

Language;Japanese

Abstract;In many patients with neuromuscular diseases, respiratory failure is mainly caused by alveolar hypoventilation in their terminal stages. Malnutrition is one of the common and serious problems in patients with chronic respiratory failure. Energy consumption for breathing is remarkably high in respiratory compromised patients, causing subsequent increase of total energy expenditure. However, most patients have limited capacity of oral intake. Nutritional depletion is associated with wasting of respiratory muscles, impairment of respiratory drive, alteration of respiratory pattern, and pathological change of pulmonary parenchyma. These indicate that nutritional and ventilatory support is very important in these patients. However, overfeeding also may have detrimental influence on respiratory failure. We experienced a Duchenne muscular dystrophy(DMD) patient on noninvasive positive pressure ventilation(NIPPV) who developed hypercapnia after total parenteral nutrition(TPN). Analysis of clinical course of this patient revealed that there is a significant correlation between PaCO2 and caloric intake. Excess carbohydrate intake can precipitate fat synthesis which induces over-production of carbon dioxide(CO2). Since NIPPV doesn't have a closed circuit, there are some difficulties in respiratory management, such as air leakage to stomach and mouth, and airway obstruction. Failure to optimize NIPPV setting against increased CO2 load might cause hypercapnia in this patient. These suggest that evaluation of energy expenditure and design of nutritional program are essential to avoid hypercapnia due to nutritional support. (author abst.)

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