|
Accession number;99A0264711
|
| Title;Encephalopathy induced by fleroxacin in a patient with Machado-Joseph disease. |
| Author;
KIMURA MASUMI
(Fukui Med. Sch.)
FUJIYAMA JIRO
(Fukui Med. Sch.)
NAGAI ATSUKO
(Fukui Med. Sch.)
HIRAYAMA MIKIO
(Fukui Med. Sch.)
KURIYAMA MASARU
(Fukui Med. Sch.)
|
Journal Title;Clinical Neurology
|
Journal Code:Z0689A
|
ISSN:0009-918X
|
|
VOL.38;NO.9;PAGE.846-848(1998)
|
| Figure&Table&Reference;FIG.1, REF.7 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Convulsive seizure with unconciousness is an adverse effect of new quinolone antibiotics including fleroxacin. A block of GABA receptor in CNS has been reported as pathomechanism. A 48-year-old female patient with Machado-Joseph disease(MJD) had encephalopathy induced by fleroxacin. She revealed unconsciousness after the administration of fleroxacin(200mg/day) for three days. Electroencephrogram(EEG) showed diffuse slow waves. The administration was discontinued and her consciousness became clear after a day. The abnormal findings on EEG disappeared gradually. The concentrations of fleroxacin were within normal limits in serum and cerebrospinal fluid. The patient with MJD might have a tendency to develop encephalopathy by fleroxacin, because the GABA-ergic nervous system could be involved in MJD. (author abst.) |
|
|
|
Related Articles;
|
|
