Single-dose Percutaneous Toxicity Study of OCT in Rats.
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Accession number;99A0490413
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| Title;Single-dose Percutaneous Toxicity Study of OCT in Rats. |
| Author;
OTABE KOJI
(Chugai Pharm. Co., Ltd.)
MATSUSHITA TOMOCHIKA
(Chugai Pharm. Co., Ltd.)
WATANABE KAZUTO
(Chugai Pharm. Co., Ltd.)
HONMA NORIO
(Chugai Pharm. Co., Ltd.)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.27;NO.Suppl.2;PAGE.S.575-S.579(1999)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Single-dose percutaneous toxicity of OCT was investigated in Sprague Dawley rats(Slc: SD). Animals were received 0(vehicle), 1,3,10 and 30mg/kg of OCT, and were observed for 14 days. Each treatment group was consisted of 5 each of males and females. The redness in the application site of skin was observed in all OCT treated animals from Day 2 to 6. In the groups of 10mg/kg or more, the body weight decreased from the day after treatment, the locomotor activity decreased on Day 3, then all male and female animals died on Day 3 or 4. In the dead animals, the histpathological examination revealed the calcification in heart, kidney and stomach, dilated tubules and protein casts in kidney. The cause of death might be the cardiac or renal failure. At the application site of skin, the thickening of epidermis was observed. In th surviving animals in 3mg/kg group, the body weight decreased until Day 4, and the calcification of stomach was observed histopathologically. From above results, the maximum tolerate dose of OCT in this study was 3mg/kg in both male and female. (author abst.) |
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