Growth of Two Children after Six Months Interruption of GH Therapy.
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Accession number;99A0391890
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| Title;Growth of Two Children after Six Months Interruption of GH Therapy. |
| Author;
KATSUSHIMA Y
(Tohoku Univ. School Of Medicine, Sendai, Jpn)
OGAWA E
(Tohoku Univ. School Of Medicine, Sendai, Jpn)
FUJIWARA I
(Tohoku Univ. School Of Medicine, Sendai, Jpn)
ASANUMA A
(Tohoku Univ. School Of Medicine, Sendai, Jpn)
IINUMA K
(Tohoku Univ. School Of Medicine, Sendai, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.46;NO.Supplement;PAGE.S43-S45(1999)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.2 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We describe two short boys with normal GH responses to the stimuli in whom GH therapy was interrupted for 6 months. Their growth rates before and after the interruption, and after re-administration of GH were evaluated. Height velocity (HV) in case 1 before and after the interruption was 6.6 cm/y and 5.0 cm/y, respectively. HV was not increased (5.0 cm/y) by re-initiation of GHtherapy despite the high serum IGF-1 level. Height velocity (HV) in case 2 before and after the interruption was 5.6 cm/y and 3.6 cm/y, respectively. HV was slightly increased to 4.1 cm/y by re-administration of GH, but it was far below the pretreatment value. Serum IGF-1 was increased by GH in this case as well. We conclude that re-acceleration of growth by re-administration of GH after interruption of therapy, as seen in classical GHD patients, may not be expected in normal short children. (author abst.) |
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