Effect of Azelnidipine, CS-905, on Diurnal Blood Pressure Variation and Heart Rate Variability in Patients with Essential Hypertension.
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Accession number;99A0447091
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| Title;Effect of Azelnidipine, CS-905, on Diurnal Blood Pressure Variation and Heart Rate Variability in Patients with Essential Hypertension. |
| Author;
TOCHIKUBO OSAMU
(Yokohamashidai I Urafunebyoin)
MIYAJIMA EIJI
(Yokohamashidai I Urafunebyoin)
KAWANO YOSHIYUKI
(Nanasawa Rehabil. Hosp.)
IWATA ATSUTO
(Yokohama City Kowan Hosp.)
ISHII MASAO
(Yokohama Senin Hoken Hosp.)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.15;NO.3;PAGE.435-450(1999)
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| Figure&Table&Reference;FIG.6, TBL.10, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effect of CS-905(8-16mg once a day) on 24-hour the blood pressure and heart rate variability was evaluated in 10 inpatients with mild to moderate essential hypertension. 1) Administration of CS-905 decreased the blood pressure both day and night, achieving excellent control over 24 hour. The maximum decrease in blood pressure occurred 8 hours after administration, with a trough/peak ratio of 58%. The standard deviation of blood pressure measurements did not increase after CS-905 was administrated. 2) The decrease in blood pressure was not associated with an increase in heart rate, nor was there any significant change in the LF/HF ratio obtained by spectral analysis of heart rate variability(LF; low frequency component, HF; high frequency component). 3) The decrease of blood pressure had no effect on endocrine parameters related to the renin-angiotensin or sympathetic nervous system. 4) Among urinary parameters such as urine volume and electrolytes, the urinary sodium excretion significantly increased. 5) Two cases of "suspected upper airway infection" and "prostate hypertrophy" were reported as incidental event, but they were not considered to be related to the test drug. No adverse effects were observed. From these results, 8-16mg/day CS-905 once daily achieved a stable hypotensive effect for 24 hours and did not cause activation of the renin-angiotensin or sympathetic nervous system activity secondary to the decrease ob blood pressure in patients with mild to moderate essential hypertension. (author abst.) |
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