Intramuscular 3-Hydroxybutyrate Levels after 60 Tetani/Min Contraction in Diabetic and Non-Diabetic Rats.
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Accession number;99A0461600
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| Title;Intramuscular 3-Hydroxybutyrate Levels after 60 Tetani/Min Contraction in Diabetic and Non-Diabetic Rats. |
| Author;
OSHIDA Y
(Nagoya Univ., Nagoya, Jpn)
SATO J
(Nagoya Univ., Nagoya, Jpn)
NAKAI N
(Nagoya Univ., Nagoya, Jpn)
SHIMOMURA Y
(Nagoya Inst. Technol., Nagoya, Jpn)
OHSAWA I
(Nagoya Univ., Nagoya, Jpn)
SATO Y
(Nagoya Univ., Nagoya, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.45;NO.3;PAGE.363-370(1998)
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| Figure&Table&Reference;FIG.6, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Post-exercise hyperketonemia in poorly-controlled diabetic patients is a well recognized phenomenon, but because studies concerning changes in ketone body metabolism in muscle during and/of after exercise are scarce, we measured the intramuscular 3-hydroxybutyrate (3-OHBA) and lactate concentrations in 12 diabetic (streptozotocin-induced; 60 mg/kg, ip) and 13 non-diabetic control rats before and after a 1-h muscle contraction. One thigh tetanic contraction was elicited at a tetanic frequency of 60 tetani/min and the other thigh was kept resting. We used a microdialysis technique in both quadriceps muscles, vastus lateralis, and the right jugular vein. Blood flow in both femoral muscles was also monitored before and after contraction. Dialysate 3-OHBA and lactate levels in contracting and non-contracting muscles and in blood showed a significant increase after contraction (P<0.05) in diabetic rats. In control rats there was no significant change in dialysate 3-OHBA or the lactate concentration in contracting and non-contracting muscles or in blood before and after contraction. A significant increase ; in contracting muscle blood flow was observed only for the first 5 min after contraction in diabetic and control rats. These results suggest that 3-OHBA uptake in contracting muscle is reduced, and that this phenomenon may play a role in post-exercise ketosis in diabetes. (author abst.) |
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