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Accession number;99A0326948
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| Title;The number of plasma exchanges in Guillain-Barre syndrome: evaluation by the removal rate of immunoglobulin G. |
| Author;
TAGAWA YUMI
(Dokkyo Univ. Sch. of Med.)
YUKI NOBUHIRO
(Dokkyo Univ. Sch. of Med.)
HIRATA KOICHI
(Dokkyo Univ. Sch. of Med.)
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Journal Title;Clinical Neurology
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Journal Code:Z0689A
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ISSN:0009-918X
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VOL.38;NO.10/11;PAGE.951-954(1998)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The optimal number of plasma exchanges in Guillain-Barre syndrome had not been established. Recently, a clinical trial by the French Cooperative Group showed that 2 exchanges were sufficient for mild case of Guillain-Barre syndrome, but all others 4 exchanges were optimal. The supplementary examination is needed to validate the conclusion, but a certain period should be taken. As the second best way to determine the appropriate number of plasma exchanges, we simply examined the reduction rate of IgG on each session. Wilcoxon signed-ranks test showed that removal rates of IgG differed between the first and second sessions, and between the second and third sessions. At least, 2 exchanges seemed to be needed for Guillain-Barre syndrome. Our results confirmed that IgG is the most relevant factor in the pathogenesis of the syndrome. (author abst.) |
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