Science Links Japan | Attenuation of Reperfusion Phenomenon by Reperfusion Using Leukocyte-Depleted Blood During Direct Percutaneous Transluminal Coronary Angioplasty for Acute Myocardial Infarction.

Attenuation of Reperfusion Phenomenon by Reperfusion Using Leukocyte-Depleted Blood During Direct Percutaneous Transluminal Coronary Angioplasty for Acute Myocardial Infarction.

Accession number;99A0408727

Title;Attenuation of Reperfusion Phenomenon by Reperfusion Using Leukocyte-Depleted Blood During Direct Percutaneous Transluminal Coronary Angioplasty for Acute Myocardial Infarction.

Author; WATANABE SHINTARO (Hitachi, Ltd., Hitachi Hosp.) ISEKI HARUKAZU (Hitachi, Ltd., Hitachi Hosp.) TANAKA KIMIO (Hitachi, Ltd., Hitachi Hosp.) ISHIBASHI HIROSHI (Hitachi, Ltd., Hitachi Hosp.) TANAKA KAZUSHI (Hitachi, Ltd., Hitachi Hosp.) TAKEI YASUHIKO (Hitachi, Ltd., Hitachi Hosp.) EJIRI NARIAKI (Hitachi, Ltd., Hitachi Hosp.)

Journal Title;J Cardiol

Journal Code:Y0264A

ISSN:0914-5087

VOL.33;NO.3;PAGE.145-152(1999)

Figure&Table&Reference;FIG.4, TBL.1, REF.21

Pub. Country;Japan

Language;Japanese

Abstract;Leukocytes are important in the occurrence of reperfusion injury in coronary intervention for acute myocardial infarction(AMI). This study compared reperfusion injury caused by reperfusion using leukocyte-depleted blood(LD) and that by conventional angioplasty(control) through the reperfusion phenomenon including reperfusion arrhythmia and additional ST elevation during direct percutaneous transluminal coronary angioplasty(PTCA) in 41 patients with 21 left anterior descending artery(LAD) lesions and 20 right coronary artery(RCA) lesions. LD was prepared from 20ml of venous blood, 20ml of mixed blood and 60ml of arterial blood from the patients(LD group; LAD-LD: n=10, RCA-LD: n=10) which was passed through a leukocyte removal filter. The blood was injected from the tip of the balloon catheter at 10ml/min during inflation for 10min before balloon deflation. The control group(LAD-control:n=11, RCA-control:n=10) underwent conventional angioplasty. The appearance of reperfusion arrhythmia[atrioventricular block(AVB)>II, accelerated idioventricular rhythm(AIVR), ventricular tachycardia(VT), ventricular fibrillation(Vf)] and measurements of STmax deviation before and after reperfusion, the differences of the STmax deviation(.DELTA.ST) and additional ST elevation(LAD: .GEQ.0.5mV increase of .SIGMA.ST in lead V1-V6, RCA: .GEQ.3mV increase of .SIGMA.ST in lead II, III and aVF) were studied. The appearance of reperfusion arrhythmias was as follows; LAD-LD: AVB 0, AIVR 1, VT 1, Vf 0, LAD-control: AVB 0, AIVR 4, VT 2, Vf 1, NS, and RCA-LD: AVB 0, AIVR 0, VT 0, Vf 0, RCA-control: AVB 2, AIVR 0, VT 1, Vf 0, NS. There was no reperfusion arrhythmia in the RCA-LD group. There was no significant difference in the appearance of reperfusion arrhythmias between the LAD-LD and LAD-control or RCA-LD and RCA-control groups.... (author abst.)

Related Articles;