The Acute Effect of the Combination Therapy of .ALPHA.-Glucosidase Inhibitor and Exercise on Postprandial Blood Glucose after Lunch in Non-Insulin-Dependent Diabetic Patients.

Accession number;99A0455003
Title;The Acute Effect of the Combination Therapy of .ALPHA.-Glucosidase Inhibitor and Exercise on Postprandial Blood Glucose after Lunch in Non-Insulin-Dependent Diabetic Patients.
Author; ARAWAKA NOBUKO (Otanishinochibyoin) KARITA AKIYO (Otanishinochibyoin) YAMAZAKI TOSHIRO (Otanishinochibyoin) SEINO HIROAKI (Otanishinochibyoin) KIKUCHI HIROAKI (Otanishinochibyoin) FUJINUMA HIROAKI (Otanishinochibyoin) ABE RYUZO (Otanishinochibyoin)
Journal Title;Journal of the Japan Diabetic Society
Journal Code:Z0279B
ISSN:0021-437X
VOL.42;NO.2;PAGE.143-147(1999)
Figure&Table&Reference;FIG.5, REF.6
Pub. Country;Japan
Language;Japanese
Abstract;To clarify the acute effects of .ALPHA.-GI and exercise on postprandial blood glucose levels after lunch in NIDDM patients, we examined eight NIDDM patients who took .ALPHA.-GI with diet and exercise therapies. Blood glucose levels after lunch had been higher than 200mg/dl before commencement of diet therapy in these patients. They were treated with combination therapies according to the following protocols: 1) only diet, 2) diet with .ALPHA.-GI, 3) diet with .ALPHA.-GI and exercise. Each patient performed exercise for 30min using a bicycle ergometer to test anaerobic threshold levels. In the present study, taking .ALPHA.-GI with diet and exercise therapies showed the greatest decrease in blood glucose levels after lunch in NIDDM patients, as compared with the other therapies. The results suggest that .ALPHA.-GI is more effective in controlling blood glucose in NIDDM patients when supplemented with diet and exercise therapies. (author abst.)