Pharmacological Effects of Three Products of Chinese Herbal Remedies on Experimental Osteoporosis Induced by Ovariectomy in Rats.
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Accession number;99A0540723
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| Title;Pharmacological Effects of Three Products of Chinese Herbal Remedies on Experimental Osteoporosis Induced by Ovariectomy in Rats. |
| Author;
YAMAGUCHI KAZUMASA
(Nihombaiorisachise)
YASHITA TOMOKO
(Nihombaiorisachise)
NAGASE TAKAHIKO
(Nihombaiorisachise)
KATO MASAMI
(Nihombaiorisachise)
SHIMIZU MASAYOSHI
(Nihombaiorisachise)
TAKAHASHI TOORU
(Zaiseidoyakuhin)
TAKAHASHI KUNIO
(Zaiseidoyakuhin)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.57;NO.1/2;PAGE.13-30(1999)
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| Figure&Table&Reference;FIG.2, TBL.20, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To examine the effects of the following 3 products of Chinese herbal remedies on menopausal bone decreasing syndrome, parameters for bone metabolism, bone weight, bone mineral density, bend moment, and others were measured using old ovariectomised, low-Ca fed female rats as the model of osteoporosis occurring before and after menopause: (1) Ekki, an internal medicine improving diseases mainly occurring women, including sedation disorders, hematogenous disorders (anemia), and blood circulation disorders, whose fundamental formulations are the same as those of Shi-motsu-to, a product of Chinese herbal remedy; (2) Panaparl, a product restoring physical strength or a subsidiary therapeutic drug for women's diseases, whose main ingredients are Hampi powder and Dioscorea powder, and (3) Panamamjin tablets, a product which has natures of Ekki and Panaparl concurrently. The rats used in the present study as osteoporosis models had been subjected to bilateral ovariectomy at a fixed interval and given low-Ca feed. The following findings were noted in the control group: urinary pyridinoline and urinary deoxypyridinoline, which are bone absorbent markers, significantly increased, and urinary Ca, a bone absorbent marker, significantly decreased or tended to decreased before bilateral ovariectomy to 17 weeks after bilateral ovariectomy; urinary IP, a bone absorbent marker, significantly increased 3 to 6 weeks after bilateral ovariectomy; blood ALP, a bone formative marker, significantly increased 3 to 17 weeks after bilateral ovariectomy; and blood osteocalcin, a bone formative marker, significantly increased 17 weeks after bilateral ovariectomy.... (author abst.) |
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