Inhibitory Effects of Independent and Concomitant Administration of a Product Consisting of a Crude Drug Including Hymenanthes leaf (Shakunage-yo), Japanese valerian, Sophora flower, and Others and Shichimotsu-koka-to Product on Blood Pressure Rise in Stroke-prone Spontaneously Hypertensive Rats(SHRSP).
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Accession number;99A0540724
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| Title;Inhibitory Effects of Independent and Concomitant Administration of a Product Consisting of a Crude Drug Including Hymenanthes leaf (Shakunage-yo), Japanese valerian, Sophora flower, and Others and Shichimotsu-koka-to Product on Blood Pressure Rise in Stroke-prone Spontaneously Hypertensive Rats(SHRSP). |
| Author;
MATSUI YUKARI
(Nihombaiorisachise)
NAGASE TAKAHIKO
(Nihombaiorisachise)
TOMIOKA MIWA
(Nihombaiorisachise)
SHIMIZU MASAYOSHI
(Nihombaiorisachise)
TAKAHASHI TOORU
(Zaiseidoyakuhin)
TAKAHASHI KUNIO
(Zaiseidoyakuhin)
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Journal Title;Pharmacometrics
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Journal Code:S0617A
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ISSN:0300-8533
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VOL.57;NO.1/2;PAGE.31-38(1999)
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| Figure&Table&Reference;TBL.7, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Inhibitory effects of independent and concomitant administration of SAIRO and SAIROYOUNG tablets, Chinese medicine products, on blood pressure rise were examined with SHRSP. SAIRO consists of extract powder of Cassia seed, Cnidium rhizome and Hymenanthes leaf, powdered Japanese valerian and powdered Sophora flower, and SAIROYOUNG tablets contain extract powder of Shichimotsu-koka-to (Astragalus root, Phellodendron bark, Rehmannia root, Peony root, Cnidium rhizome, Japanese angelica root and Uncaria uncinus cum stem). Test compounds were given to SHRSP for 5 consecutive weeks during the time when the animals reached from the age of 6 weeks to the age of 11 weeks. The animals excluding those of the non-treated control group were loaded with a 1% solution of saline during the 5-week dosing period. Compared with the non-treated control value, blood pressure in the control group, which was loaded with the 1% saline solution, significantly rose from 1 week after initiation of administration. Rises in blood pressure were inhibited in the animals treated independently with SAIRO and SAIROYOUNG tablets. Concomitant administration of SAIRO and SAIROYOUNG tablets kept the values of blood pressure at almost the same as the corresponding non-treated control value until 2 weeks after initiation of administration; it was confirmed that inhibitory effects of SAIRO and SAIROYOUNG tablets on blood pressure rise were strengthened by concomitant administration. However, when SAIRO and SAIROYOUNG tablets were administrated independently, neither of them had life-prolongation effect. Nor did concomitant administration of SAIRO and SAIROYOUNG tablets have long-prolongation effect. Body weight in all test groups increased until 4 weeks after initiation of administration, but that in the groups loaded with the 1% saline solution, whose animals died, decreased thereafter.... (author abst.) |
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